Research, Development & Manufacturing

Research, Development & Manufacturing

Science-led development, built around the regulatory pathway

Raised Pharma takes a product from an idea on paper to a licensed, market-ready dosage form. We work as the development and manufacturing partner for pharmaceutical manufacturers, healthcare brands and supplement companies who need the science, the documentation and the regulatory pathway handled as one piece of work rather than three.

Every programme is designed backwards from its destination. Before a single trial batch is made, we establish which authority will review the file — Health Canada, the FDA, the EMA, or SFDA, EDE, MOPH, NHRA and the GCC-DR route — because the classification, the specification and the evidence expected all follow from that decision.

Our Approach

Regulatory pathway first

The target market defines the product. We confirm classification and the expected data package at the outset, so formulation work, specifications and the stability programme are all built to satisfy the file rather than reworked to fit it later.

Built to be reproducible

A formulation that only works once is not a formulation. Development runs with scale-up and technology transfer already in view — process parameters, equipment fit and material specifications documented as we go.

Quality designed in, not inspected in

Analytical methods, in-process controls and acceptance criteria are defined alongside the formulation, so quality is a property of the process and not something checked for at the end.

One accountable partner

Formulation, sourcing, analytical work, stability, technology transfer, validation and the regulatory submission sit under one team, so nothing is lost in the handover between specialists.

From Molecule to Market

Nine stages. Some programmes need all of them; most need a defined subset. Scope is agreed with you before work begins.

01
Pre-formulation

Characterisation of the active — solubility, particle size, polymorphic form, hygroscopicity — and excipient compatibility screening. This is where most late-stage failures are prevented.

Typical deliverables Pre-formulation report, excipient compatibility data, target product profile

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02
Formulation development

Prototype formulations across the chosen dosage form, screened for content uniformity, dissolution, physical stability and manufacturability. Iterated until a robust lead formulation is selected.

Typical deliverables Lead formulation, master formula, trial batch records

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03
Analytical method development

Assay, related substances, dissolution and content uniformity methods developed and validated to demonstrate they are specific, accurate, precise and stability-indicating.

Typical deliverables Analytical methods, method validation protocol and report

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04
Raw material sourcing & vendor qualification

APIs, excipients and packaging sourced against agreed specifications, with supplier documentation reviewed and audits carried out where the risk profile calls for it.

Typical deliverables Material specifications, CoAs, supplier qualification and audit reports

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05
Stability studies

Long-term, intermediate and accelerated conditions selected against the applicable guideline and climatic zone for the target market, with pull points and test parameters defined in a written protocol.

Typical deliverables Stability protocol, interim and final stability reports, shelf-life justification

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06
Clinical & bioequivalence study support

Where a study is required, we support the supply side — clinical trial material manufacture, comparator sourcing, placebo matching and stability of clinical batches — working alongside your CRO or bioequivalence partner.

Typical deliverables Clinical trial material, batch documentation, comparator and placebo supply

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07
Scale-up & technology transfer

Process moved from laboratory to production scale, or from a sending site to a receiving site, with parameters, equipment fit, analytical methods and material alignment documented through the transfer.

Typical deliverables Technology transfer protocol, scale-up batch data, method transfer report

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08
Validation & commercial supply

Process validation protocols (PVP), execution and reports (PVD, PVR), cleaning validation and the QA documentation set that supports routine commercial manufacture.

Typical deliverables Validation protocols and reports, batch records, release documentation

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09
Regulatory registration

Dossier compilation and submission support for the target market, and management of queries through to licence, followed by post-market variation support.

Typical deliverables Registration dossier, submission package, query responses

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Technologies & Capabilities

Three dosage-form platforms, developed for pharmaceutical, natural health product and cosmetic applications.

Oral Solid Dosage Forms
  • Immediate-release and film-coated tablets
  • Hard-shell capsules, including liquid and powder fill
  • Sustained, delayed and modified-release systems
  • Effervescent, chewable and dispersible tablets
  • Powders, granules and sachet presentations

Processes Direct compression, wet and dry granulation, fluid-bed processing, blending, encapsulation, coating.

Oral Liquid Dosage Forms
  • Solutions, syrups and elixirs
  • Suspensions and reconstitutable powders
  • Oral drops and paediatric presentations
  • Preservative systems and taste-masking
  • Multi-dose and unit-dose packaging

Processes Solubilisation, homogenisation, viscosity and pH control, microbiological and preservative-efficacy considerations.

Topical & Semisolid Dosage Forms
  • Creams, lotions and emulsions
  • Gels, hydrogels and clear systems
  • Ointments and anhydrous bases
  • Cosmetic and personal-care formats
  • Tubes, jars, airless pumps and sachets

Processes Emulsification, phase behaviour, rheology, penetration-enhancer selection, container-closure compatibility.

Development, Manufacturing & Quality Services

Manufacturing & Technology Transfer

Moving a validated process without losing it is a discipline of its own. We manage transfer in both directions — laboratory to production, or site to site — covering the documentation package (master formula, batch records, specifications, analytical methods), equipment and facility fit, raw material and vendor alignment, process parameters, trial and validation batches, the stability commitment on the receiving site, and any regulatory notification or variation the move triggers.

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Quality Assurance & Validation

Process validation protocols and reports, cleaning validation, analytical method validation and the in-process control strategy that sits behind them. We write the protocols to be executed and defended, not to sit in a binder — each acceptance criterion traceable to a specification and each specification traceable to the registered file.

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Supplier Qualification & Audits

API, excipient, packaging and contract manufacturing sites assessed against a structured audit framework: licences, quality management system, GMP compliance, documentation and traceability, materials handling, change control and deviations, sub-contracting and regulatory history — closing with a risk rating and an approve, conditional or reject recommendation.

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Troubleshooting & Remediation

Programmes that have stalled — a failing dissolution profile, a stability signal, a rejected submission, a transfer that will not reproduce at the receiving site. We diagnose against the data, identify the root cause and define the corrective work needed to get the product moving again.

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Please note: this page describes the development, manufacturing and quality services Raised Pharma provides on a contract basis. The exact scope, dosage form, analytical package and regulatory route for any programme are defined and agreed before work begins. Nothing here constitutes regulatory, legal or medical advice, and no submission, label, claim or specification should be filed or used without review by a qualified regulatory professional.

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